The ‘skinny’ on GLP-1 meds

GLP-1 agonists are the newest anti-obesity medication to hit the market. They were originally marketed for diabetes, but during studies were found to cause significant weight loss. There are multiple GLP-1 agonists available, some of which are marketed only for diabetes, and others that are available for either diabetes or obesity. They have become increasingly popular over the past year or so which has led to multiple drug shortages.

How do GLP1s cause weight loss?

GLP-1s mimic the hormone Glucagon-like-peptide or GLP which has roles in regulating blood sugar. The exact mechanism that GLP-1s use to cause weight loss isn’t clear, but we know that GLP-1s not only make people feel less hungry but also feel full faster – so these people eat less and, as a result, lose weight. The medication isn’t a magic bullet; when it is stopped, the benefits on appetite and fullness will disappear and people will often regain weight.

How much weight do people lose?

Weight loss will vary from one person to another. In studies, people on GLP-1s lost an average of 15% of their initial weight over a year (when combined with diet and lifestyle modifications). This percentage of weight loss is much higher than what is seen with other anti-obesity medications (3-8% is typical) or with diet and exercise alone (up to 7-10%).

Sounds too good to be true… What’s the risk?

All medications have risks – typically medications are prescribed if the provider feels that the benefits of the medication outweigh the risks. GLP-1s slow down gastric emptying (making people feel full longer). This slowing can also cause nausea, constipation, heartburn, and GI discomfort. As with all medications, there is a risk of serious complications, although this is rare.

How can I get a GLP1?

Because of their popularity, there have been intermittent drug shortages over the past year or so. Manufacturers are working to increase production to meet the soaring demand, but this has been a slow process leaving patients (and providers) feeling frustrated at times. There are multiple GLP-1s currently being studied. It is expected that there will be more options coming to market over the next year or so. Hopefully, this will lead to greater competition (decreasing prices) and fewer shortages. Insurance coverage varies - check with your plan to determine coverage.

BUT, the first step is to meet with Cody or Stephanie to determine if a GLP-1 medication is the right fit for you!